Chemokine RANTES/CCL5 from Jawbone Cavitation – Hidden Interface to Systemic - Immunological Diseases - 2021 ESMED General Assembly

Chemokine RANTES/CCL5 from Jawbone Cavitation – Hidden Interface to Systemic - Immunological Diseases By. Dr. Johann Lechner, Head of Clinic Integrative Dentistry Munich Abstract: Why are jawbone cavitations a hidden interface to systemic-immunological diseases (SID)? How to detect Jawbone Cavitations? A major problem is that a jawbone with fatty-degenerative osteolysis (FDOJ) appears without abnormal findings in X-ray examination. Our data revealed a discrepancy between the X-ray density of dental 2D-OPGs and bone marrow defects in jawbone like FDOJ/”NICO”. Being virtually undetectable by X-ray the occurrence of FDOJ/” NICO” remain widely unknown and even are denied. This suggests a critical attitude toward the use of 2D-OPG as a sole imaging diagnostic tool for assessing FDOJ cavitations. 2D-OPG is objectively not suitable for depicting FDOJ. Conclusion #1: To overcome this problem the use of Through-Transmission Alveolar Ultrasonography (TAU) was evaluated. This approach by new CaviTAU® is radiation free, not user dependent and clinically approved. Why are jawbone cavitations a dangerous interface to systemic-immunological diseases (SID)? We investigated in depth the tissue in FDOJ lesions which appears as a clump of fat inside of an intact cortical bone. This tissue is in an ischemic, fatty degenerative state and are biochemically exceedingly active, producing certain zytokines in high amounts, namely RANTES/CCL-5 (R/C). Conclusion #2: FDOJ bone marrow defects in jawbone produce chronic R/C overexpression. Immune messenger RANTES/CLL5 is elevated in many systemic-immunological diseases (SID). The level of R/C is also elevated in a number of SIDs such as cancer, depression, multiple sclerosis or arthritis. There is strong evidence that the development and the persistency of a variety of SID can be related to the R/C overexpression in FDOJ. Conclusion #3: Hence, serious health risks can be associated with fatty-degenerative osteolysis of the jawbone. New TAU apparatus CaviTAU provides pictures in 2D and 3D to depict FDOJ lesions as a source of chronic-inflammatory R/C signaling to build up SID. Eliminating this R/C source might hinder SID to propel further. More details will be at 2021 ESMED General Assembly For more see Facebook of ESMED General Assembly and Youtube of European Society of Medicine

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