European Society of Medicine - list of abstracts for conferences and other related information

Chemokine RANTES/CCL5 from Jawbone Cavitation – Hidden Interface to Systemic - Immunological Diseases By. Dr. Johann Lechner, Head of Clinic Integrative Dentistry Munich Abstract: Why are jawbone cavitations a hidden interface to systemic-immunological diseases (SID)? How to detect Jawbone Cavitations? A major problem is that a jawbone with fatty-degenerative osteolysis (FDOJ) appears without abnormal findings in X-ray examination. Our data revealed a discrepancy between the X-ray density of dental 2D-OPGs and bone marrow defects in jawbone like FDOJ/”NICO”. Being virtually undetectable by X-ray the occurrence of FDOJ/” NICO” remain widely unknown and even are denied. This suggests a critical attitude toward the use of 2D-OPG as a sole imaging diagnostic tool for assessing FDOJ cavitations. 2D-OPG is objectively not suitable for depicting FDOJ. Conclusion #1: To overcome this problem the use of Through-Transmission Alveolar Ultrasonography (TAU) was evaluated. This approach by new...

Polynucleotide ruthenium organometallic compounds induce DNA damage identified by human NER factor XPC By Dr. Steven Shell, The University of Virginia’s College at Wise Abstract: Ruthenium organometallic compounds represent an attractive avenue in developing alternatives to platinum-based chemotherapeutic agents. While evidence has been presented indicating ruthenium-based compounds interact with isolated DNA in vitro, it is unclear what effect these compounds exert in cells. Moreover, the antibiotic efficacy of polynuclear ruthenium organometallic compounds remains uncertain. In this study we report that exposure to polynuclear ruthenium organometallic compounds induces recruitment of damaged DNA sensing protein Xeroderma pigmentosum Group C (XPC) into chromatin-immobilized foci. Additionally, we observed one of the tested polynuclear ruthenium organometallic compounds displayed increased cytotoxicity against human cells deficient in nucleotide excision repair (NER). Taken toge...

Occupational, Toxicological and Environmental Health Hazards of Global Migrant Workers By Dr. Timothy Erickson, Mass General Brigham, Harvard Medical School, Harvard Humanitarian Initiative Abstract: An increasing portion of global agricultural and industrial workforce is immigrant, undocumented and unprotected. Migrant workers are at increased risk for occupational, toxicological and environmental health hazards. Specifically, they are at risk for chemical and pesticide exposure without proper protection and well as environmental heat and cold-related illness. These workers tend to work in more dangerous industries, and safety training and information are often not available in their native language. They are often not empowered to advocate for improved working conditions because of fear of losing their jobs or deportation. They may have limited access to health care because of their unstable employment situation, low socioeconomic status, and lack of understanding of the health sys...

Results of 105 patients, most with athymia, who received cultured thymus tissue implants (CTTI) By Dr. Mary Markert, Duke University Medical Center Abstract: Background: One hundred and three infants with congenital athymia and 2 with severe combined immune deficiency (SCID) have been treated with cultured thymus tissue implantation (CTTRRI) over the past 27 years at a single center. Objectives: Objectives of the study were to assess outcomes including survival, T cell numbers and function, adverse events, and infections. Methods: All patients were enrolled under one of 10 IRB approved protocols. Eligibility was based on naïve T cells lower than 50/mm3 in both typical (no rash) and atypical (rash and lymphadenopathy) groups. A statistical plan was submitted to the Food and Drug Administration (FDA) to be used for all patients regardless of the protocol they were enrolled in. Ten patients who did not meet criteria for CTTI were enrolled in an expanded access protocol and we...

Diazadispiroalkane derivatives - new viral entry inhibitors By Dr. Elke Prof. Dr. Bogner, Charité-Universitätsmedizin Berlin, Institute of Virology Abstract: Herpesviruses are widespread and can cause serious illness. Many currently available antiviral drugs have limited effects, result in rapid development of resistance and often exhibit dose-dependent toxicity. Especially for human cytomegalovirus (HCMV) new well-tolerated compounds with novel mechanisms of action are urgently needed. We investigated the antiviral effect of two small molecules (11826091 and 11826236) on HCMV infected human embryonic lung fibroblasts. Both substances were well tolerated and exhibited a strong dose dependent antiviral activity. Time of addition assays where 11826091 or 11826236 was added to cells before, before and during, during or after infection demonstrated an inhibitory effect on early steps Interestingly, 11826236 had an effect by addition to cells after infection. Detailed studies revealed th...