Contact ESMED

For any questions feel free to contact people at ESMED directly. This blog is strictly personal with me trying to help to sort the things.

Popular posts from this blog

The anacardic 6-pentadecyl salicylic acid induces apoptosis in breast cancer tumor cells, immunomodulation in the host, and decreases blood toxic effects of classical antineoplastic agents - ESMED

Libia Vega, Centre for Research and Advances Studies of the National Polytechnic Institute "Many classical antineoplastic agents induce myelosuppression, leukopenia and immunosuppression as secondary effects in patients reducing their quality of life and generating an increase in their incidence of infections. The development of anticancer agents that simultaneously provoke antitumor immune response represents an important therapeutic advance. The administration of 6-pentadecyl salicylic acid (6SA) contributes to the antitumor immunity as it pre-activates T lymphocytes and natural killer cells, and it induces macrophage polarisation that could contribute to the antitumoral respond against 4T1 stage IV-breast cancer cells in Balb/c female mice. 6SA increases the proportion of immune cells in blood, lymph nodes, bone marrow, and of tumor-infiltrated natural killer cells and cytotoxic T lymphocytes. It also increases the secretion of interleukin (IL)-2, IL-12, Granulocyte/Monocyte ...
Read more

2021 ESMED General Assembly - Polynucleotide ruthenium organometallic compounds induce DNA damage identified by human NER factor XPC

Polynucleotide ruthenium organometallic compounds induce DNA damage identified by human NER factor XPC By Dr. Steven Shell, The University of Virginia’s College at Wise Abstract: Ruthenium organometallic compounds represent an attractive avenue in developing alternatives to platinum-based chemotherapeutic agents. While evidence has been presented indicating ruthenium-based compounds interact with isolated DNA in vitro, it is unclear what effect these compounds exert in cells. Moreover, the antibiotic efficacy of polynuclear ruthenium organometallic compounds remains uncertain. In this study we report that exposure to polynuclear ruthenium organometallic compounds induces recruitment of damaged DNA sensing protein Xeroderma pigmentosum Group C (XPC) into chromatin-immobilized foci. Additionally, we observed one of the tested polynuclear ruthenium organometallic compounds displayed increased cytotoxicity against human cells deficient in nucleotide excision repair (NER). Taken toge...
Read more

2021 ESMED General Assembly - Diazadispiroalkane derivatives - new viral entry inhibitors

Diazadispiroalkane derivatives - new viral entry inhibitors By Dr. Elke Prof. Dr. Bogner, Charité-Universitätsmedizin Berlin, Institute of Virology Abstract: Herpesviruses are widespread and can cause serious illness. Many currently available antiviral drugs have limited effects, result in rapid development of resistance and often exhibit dose-dependent toxicity. Especially for human cytomegalovirus (HCMV) new well-tolerated compounds with novel mechanisms of action are urgently needed. We investigated the antiviral effect of two small molecules (11826091 and 11826236) on HCMV infected human embryonic lung fibroblasts. Both substances were well tolerated and exhibited a strong dose dependent antiviral activity. Time of addition assays where 11826091 or 11826236 was added to cells before, before and during, during or after infection demonstrated an inhibitory effect on early steps Interestingly, 11826236 had an effect by addition to cells after infection. Detailed studies revealed th...
Read more