The anacardic 6-pentadecyl salicylic acid induces apoptosis in breast cancer tumor cells, immunomodulation in the host, and decreases blood toxic effects of classical antineoplastic agents - ESMED

Libia Vega, Centre for Research and Advances Studies of the National Polytechnic Institute "Many classical antineoplastic agents induce myelosuppression, leukopenia and immunosuppression as secondary effects in patients reducing their quality of life and generating an increase in their incidence of infections. The development of anticancer agents that simultaneously provoke antitumor immune response represents an important therapeutic advance. The administration of 6-pentadecyl salicylic acid (6SA) contributes to the antitumor immunity as it pre-activates T lymphocytes and natural killer cells, and it induces macrophage polarisation that could contribute to the antitumoral respond against 4T1 stage IV-breast cancer cells in Balb/c female mice. 6SA increases the proportion of immune cells in blood, lymph nodes, bone marrow, and of tumor-infiltrated natural killer cells and cytotoxic T lymphocytes. It also increases the secretion of interleukin (IL)-2, IL-12, Granulocyte/Monocyte Colony Stimulating Factor, Tumor Necrosis Factor-α and Interferon-γ, and significantly reduces IL-10 and IL-17 secretion, suggesting that the reduction of regulatory T cells and Tumor-Associated Macrophages contribute to the host control of tumor development. Aditionally, 6SA produces a considerably antitumoral effect by inducing apoptosis in tumor cells, and it can induce cytoprotection of immune cells against the toxic effects of classical antineoplastic agents such as Cisplatin, Carboplatin, Taxol, and 5-Fuorouracil, increasing the overall survival of the animals and improving their quality of life." For more details please visit our website https://esmed.org/ and our YouTube channel below https://www.youtube.com/channel/UCp4b1lcWovYNFEKdvat-rQw/ and Twitter feed https://twitter.com/EuropeanSociet2 2021 European Society of Medicine General Assembly Interesting info from past conferences located here https://www.slideshare.net/MOsman14 and owner LinkedIn https://www.linkedin.com/in/m-osman-5b6887206/

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