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Comprehensive molecular analysis of 61 Egyptian families with hereditary nonsyndromic hearing loss - ESMED

Maha Abdelgaber Abdellah Aly, Lecturer of Audiovestibular medicine, Faculty of Medicine, Assiut university, Egypt. Nonsyndromic hearing loss is an extremely heterogeneous disorder. Thus, clinical diagnostics is challenging, in particular due to differences in the etiology of hearing loss between populations. With this study, we wanted to elucidate the genetic basis of hearing loss in 61 consanguineous Egyptian families. In 25 families, linkage analysis was used as a prescreening to identify regions for targeted sequencing of candidate genes. Initially, the coding regions of 12 and later of 94 genes associated with hearing loss were enriched and subjected to massively parallel sequencing (MPS) with diagnostic yields of 36% and 75%, respectively. Causative variants were identified in 48 families (79%). They were found in 23 different genes with the majority being located in MYO15A (15.3%), SLC26A4 (9.7%), GJB2 (8.3%), and MYO7A (6.4%). As many as 32 variants were novel ones at the time ...
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The anacardic 6-pentadecyl salicylic acid induces apoptosis in breast cancer tumor cells, immunomodulation in the host, and decreases blood toxic effects of classical antineoplastic agents - ESMED

Libia Vega, Centre for Research and Advances Studies of the National Polytechnic Institute "Many classical antineoplastic agents induce myelosuppression, leukopenia and immunosuppression as secondary effects in patients reducing their quality of life and generating an increase in their incidence of infections. The development of anticancer agents that simultaneously provoke antitumor immune response represents an important therapeutic advance. The administration of 6-pentadecyl salicylic acid (6SA) contributes to the antitumor immunity as it pre-activates T lymphocytes and natural killer cells, and it induces macrophage polarisation that could contribute to the antitumoral respond against 4T1 stage IV-breast cancer cells in Balb/c female mice. 6SA increases the proportion of immune cells in blood, lymph nodes, bone marrow, and of tumor-infiltrated natural killer cells and cytotoxic T lymphocytes. It also increases the secretion of interleukin (IL)-2, IL-12, Granulocyte/Monocyte ...
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Peripheral Vein Thrombophlebitis in the Upper Extremity: a Frequent and Important Problem - ESMED

Shu Yun Heng, Singapore General Hospital "The acceptable incidence of thrombophlebitis following intravenous cannulation is 5%, as recommended by the Intravenous Nurses Society guidelines, but publications have reported startling figures of 20% to 80%. Given the frequency of intravenous lines, this presents a potential clinical problem. Thrombophlebitis can progress despite antibiotics to become a challenging clinical problem requiring surgical intervention. We aimed to determine the predisposing patient, catheter, and health care-related factors of peripheral vein thrombophlebitis in the upper extremity. We reviewed our experience of surgical intervention with analysis of the indications for intervention, description of the surgical procedures and outcomes. Qualitative syntheses revealed that patient-related factors that confer a higher risk included intercurrent illness, immunocompromised state, comorbidities such as diabetes mellitus, malignancy, previous thrombophlebitis, bu...
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The emerging role of simulation in teaching sinus surgery - ESMED

Philip Chen, University of Texas Health at San Antonio Endoscopic sinus surgery is a commonly performed surgery, but learning to operate in a confined space with variable anatomy in a 2-dimensional view can be challenging. Simulation is being increasingly used to teach various types of surgery including endoscopic sinus surgery. Goals of simulation include faster learning in a safe environment. However, creation of valid models is challenging and an area for growth. For more details please visit our website https://esmed.org/ and our YouTube channel below https://www.youtube.com/channel/UCp4b1lcWovYNFEKdvat-rQw/ and Twitter feed https://twitter.com/EuropeanSociet2 2021 European Society of Medicine General Assembly Interesting info from past conferences located here https://www.slideshare.net/MOsman14 and owner LinkedIn https://www.linkedin.com/in/m-osman-5b6887206/
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European Society of Medicine - Pathophysiological comparison and management of COVID-19 and influenza in Japan

By Dr. Masafumi Seki, Tohoku Medical and Pharmaceutical University, Sendai city, Japan Abstract: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become a historic pandemic, and dealing with it is one of the most important aspects of infectious disease treatment today. SARS-CoV-2 has been found to have characteristic and powerful infectivity (ability to propagate) and lethality (severity). With influenza, primary influenza pneumonia from the virus itself is known to exist in addition to secondary bacterial pneumonia. With COVID-19, on the other hand, it is important to provide diagnosis and treatment while keeping acute respiratory distress syndrome and pulmonary edema (alveolar flood) from a similar cytokine storm, as well as severe angiopathy, in mind. The importance of complying with hand hygiene and masks in infection control remains the same as in previous general infection control measures and resp...
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European Society of Medicine - Infective endocarditis and meningitis due to Scedosporium prorilficans in a renal transplant recipient

By Dr. Kenji Uno, Department of Infectious Diseases, Minami-Nara General Medical Center Abstract: Scedosporium prolificans is a ubiquitous filamentous fungi that may cause disseminated diseases in neutropenic patients with hematological malignancies. We report a fatal case of renal transplant recipient who developed both infective endocarditis and meningitis due to S. prolificans during treatment with micafungin and itraconazole for chronic necrotizing aspergillosis. Breakthrough Scedosporium infection should be considered among differential diagnosis of invasive fungal diseases in patients with renal transplant recipients receiving antifungal agents. For more details please visit our website https://esmed.org/ and our YouTube channel below https://www.youtube.com/channel/UCp4b1lcWovYNFEKdvat-rQw/ and Twitter feed https://twitter.com/EuropeanSociet2 2021 European Society of Medicine General Assembly Interesting info from past conferences located here https://www.slideshare.net/MO...
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European Society of Medicine - Acute Peritoneal Dialysis with Percutaneous Catheter Insertion for COVID-19-associated Acute Kidney Injury in Intensive Care: Experience from a UK Tertiary Centre

By Dr. Elaine Bowes, Kings College Hospital NHS Trust London Abstract: Results :37 / 44 successful catheter insertions and commenced PD 5 unsuccessful due to abdominal obesity / failure to reach peritoneum using 50mm needle 1 abandoned due to complication from omental obstruction 1 abandoned due to suspicion of needle puncture of the bowel; retried on following day as pt stable but unable to advance guidewire No cases of bladder injury, haemorrhage, or catheter-associated leaks 27/37 (73%) were receiving PD at the time of their renal recovery or death 10/37 (27%) were switched to CRRT or HD without returning to PD 3 rapidly deteriorating from MOF and CRRT felt more appropriate 3 switched due to ICU clinician preference 1 scrotal leak 1 abdominal pain (peritonitis excluded) 1 pulled out tube while delirious 1 planning for proning and team preferred CRRT rather then PD prone trial Also 16 temporary episodes of alternative RRT before returning to PD (median duration 48 hours, IQR 24,...
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